By Ann Arvin, Gabriella Campadelli-Fiume, Edward Mocarski, Patrick S. Moore, Bernard Roizman, Richard Whitley, Koichi Yamanishi
This definitive and finished account of the human herpes viruses offers an encyclopedic evaluation in their uncomplicated virology and medical manifestations. This crew of viruses comprises human simplex kind 1 and a couple of, Epstein Barr virus, cytomegalovirus and varicella-zoster virus. The illnesses they reason are major and sometimes recurrent. Their incidence within the constructed global bills for a big burden of disorder, and for that reason there's a good deal of analysis into the pathophysiology if an infection and immunobiology. one other vital zone coated inside of this quantity issues antiviral remedy and the improvement of vaccines. these kinds of facets are lined intensive and the quantity is absolutely brand new either scientifically and when it comes to scientific instructions for sufferer care. The textual content is generously illustrated all through and entirely referenced to the most recent learn and advancements.
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Extra info for Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis
1 shows the major classes of genome structure found among the herpesviruses, as summarized by Roizman and Knipe (2001). The class A genome consists of a unique sequence ﬂanked by a direct repeat. , 1996) and one member of the Gammaherpesvirinae (EHV-2; Browning and Studdert, 1989). In these examples, the direct repeat is several kbp in size. , 1996). 3 kbp. , 1996). , 1976; Lagunoff and Ganem, 1997). , 1989). The virion DNA of this virus exhibits segment inversion because the two unique regions are ﬂanked by inverted repeats.
H. V. (1990). Virus species, a much overlooked but essential concept in virus classiﬁcation. Intervirology, 31, 241–254. Wildy, P. (1971). Classiﬁcation and nomenclature of viruses. In Monographs in Virology, vol. 5, ed. J. L. , pp. 33–34. Basel: Karger. 9 2 Comparative analysis of the genomes Andrew J. Davison MRC Virology Unit, Institute of Virology, Glasgow, UK Introduction Members of the family Herpesviridae replicate their genomes in the infected cell nucleus and have a characteristic virion morphology, which consists of the envelope, tegument, capsid and core (Davison and Clements, 1997).
Megaw, A. , and Davison A. J. (1998). The DNA sequence of the RK strain of human herpesvirus 7. Virology, 244, 119–132. Midgley, R. , Bell, A. , McGeoch, D. , and Rickinson, A. B. (2003). Latent gene sequencing reveals familial relationships among Chinese Epstein–Barr virus strains and evidence for positive selection of A11 epitope changes. J. , 77, 11517–11530. Mitchell, M. , and Rao, V. B. (2002). Sequence analysis of bacteriophage T4 DNA packaging/ terminase genes 16 and 17 reveals a common ATPase center in the large subunit of viral terminases.
Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis by Ann Arvin, Gabriella Campadelli-Fiume, Edward Mocarski, Patrick S. Moore, Bernard Roizman, Richard Whitley, Koichi Yamanishi