Viral Messenger RNA: Transcription, Processing, Splicing and by Joseph R. Nevins (auth.), Yechiel Becker, Julia Hadar (eds.) PDF

By Joseph R. Nevins (auth.), Yechiel Becker, Julia Hadar (eds.)

ISBN-10: 1461296218

ISBN-13: 9781461296218

ISBN-10: 1461325854

ISBN-13: 9781461325857

The nucleotide series of the gene from which messenger RNA mole­ cules are transcribed is in a sort that may be translated through mobile ribosomes into the amino acid series of a specific polypeptide, the made of the gene. the invention of messenger RNA greater than 20 years in the past resulted in a sequence of experiences on its association and serve as in cells within the presence of infecting viruses. This quantity is dedicated to present stories within the box of mobile and viral messenger RNA. The stories offered supply an perception into molecular and genetic facets of messenger RNA. distinctive recognition was once paid through the authors to the molecular association of mRNA species, to the processing of mRNA molecules, and to the several suggestions hired by means of DNA and RNA viruses within the synthesis in their mRNA. the power of a virulent disease to take over the protein-synthesizing mechanisms of an contaminated mobile is determined by its skill to supply mRNA molecules that can have an effect on the host mRNA or make the most of mobile parts extra successfully. the variations among, and similarities of, the innovations of mRNA synthesis devised by way of quite a few DNA and RNA viruses are defined herein. This publication will be of curiosity to all scholars of mobile and viral genes and scientists within the box. it truly is appropriate as a textbook for workshops and classes on mRNA. I desire to thank the authors for his or her wonderful contributions and for his or her interest.

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Additional info for Viral Messenger RNA: Transcription, Processing, Splicing and Molecular Structure

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These results support the concept that a direct interaction between mRNA and eIF-2 occurs at initiation of translation and suggest a relationship between the affinity of an mRNA for eIF-2 on one hand, and its ability to compete in translation on the other (42, 45). :: Q. 7 ~Q E Q. 120 • 100 :! ! ci v ~ 0 FRACTION NUMBER Fig. 13. Co-purification of the activity that relieves translational competition with eIF~2. For purification of eIF-2, see ref. 27. The gradient portion of the phosphocellulose column is shown.

The mRNA-binding property is a function of eIF-2 itself. Thus, eIF-2 is preferentially retained on mRNA-cellulose columns and upon elution is active in translation and in GTP-dependent binding of Met-tRNAf (12, 26). Binding of Met-tRNAf is inhibited competitively by mRNA (24, 11, 25, 14). Most convincingly, binding of mRNA to purified eIF-2 preparations can be inhibited completely by competing amounts of Met-tRNAf' 25 t ~ ------~------------------~--~ \J \j : ... '. ' '-,:; ( , ,/l ... - , 2 ......

A. Cell 15: 497-510. J. Virol. C9. Shatkin, A. J. 1978. Cell 14: 695-711. 1978. Cell 9: 645-653. 1980. 1976. 70. , Nevins, J. R. and Darnell, J. E. 1980. 72. HoI. Biol. 134: J. Hicrobiol. Rev. 44: 175-205. 71. Hoss, B. and Koczot, F. 1978. 25: 897-906. C,7. Chow, L. T. , Broker, T. R. and Lewis, J. B. 265-303. 1979. CR. Banerjee, A. K. 1978. Proe. Nat'l. Acad. Sci. USA 75: C3. HeGrogan, H. and Raskas, H. J. 625-629. 1978. 64. Chow, L. T. and Broker, T. R. J. Virol. 25: 811-823. Nature 287: 246-248.

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Viral Messenger RNA: Transcription, Processing, Splicing and Molecular Structure by Joseph R. Nevins (auth.), Yechiel Becker, Julia Hadar (eds.)


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